GitHub
ACTIVE RESEARCH FOCUS

Mapping the evolution of epigenetic aging across species.

Leveraging high-dimensional DNA methylation data and computational phylogenetics to decode the molecular clock of mammalian longevity.

This page presents active research projects in DNA methylation aging, comparative epigenomics, and evolutionary genomics.

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PROJECT_ID: MAMMALIAN_DNAM_01

Mammalian DNAm aging & longevity project

Comparative Genomics Machine Learning Epigenetics

COMPUTATIONAL METHODS

  • Elastic Net Regression
  • Phylogenetic Independent Contrasts
  • Maximum Likelihood Estimation
  • Random Forest Importance
FIG. 01: PHYLOGENETIC CLOCK
Evolutionary drift of epigenetic markers across phylogenetic branches.
FIG. 02: METHYLATION HEATMAP
Conserved methylation sites associated with maximum lifespan.
ONGOING_WORK

Single-cell Epigenetic Drift in Aging Hearts

#snMethyl-seq #CardioAging
DATA_ARCHIVE
PCA: CLUSTER_04
Clustering Signatures

Dimensionality reduction of 27,000 CpG sites across evolutionary lineages.

ALGORITHM_DEV

EvoClock.py

VIEW ON GITHUB

Network Epigenomics